Variable protein homeostasis in housekeeping and non-housekeeping pathways under mycotoxins stress.

ABSTRACT: Transcript levels are the primary factor determining protein levels, but for the majority of genes, fold changes in transcript levels are larger than the corresponding changes in protein levels, a phenomenon that is termed "protein homeostasis". However, this phenomenon is not well characterized in the context of environmental changes. In this study, we sequenced the entire transcriptome and proteome of chicken primary hepatocytes administered three mycotoxin treatments Aflatoxin B₁ (AFB₁), Ochoratoxin A (OTA) and Zearalenone (ZEN). Each mycotoxin induced unique set of differential expressed transcripts and proteins, suggesting variable cytotoxicity and biochemical action in cell. We found a weak positive correlation between transcript and protein changes, and the tra

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6534621 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature