Association of antidiabetic medication and statins with breast cancer incidence in women with type 2 diabetes.

ABSTRACT:

Purpose

To address the possible association between the use of metformin, other forms of antidiabetic medication (ADM) and statins with the incidence of breast cancer in women with type 2 diabetes (T2D).

Methods

Data were collected from a Finnish nationwide diabetes database (FinDM). The study cohort consisted of women diagnosed with T2D in 1996-2011 in Finland. In full-cohort analysis, Poisson regression was used to estimate hazard ratios (HRs) in relation to use of metformin, insulin, other forms of oral ADM and statins. In nested case-control analysis, up to 20 controls were matched for age and duration of diabetes to each case of breast cancer. Conditional logistic regression was used to estimate HRs in relation to medication use and cumulative use of different forms of

SUBMITTER: Hosio M 

PROVIDER: S-EPMC6534663 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature