Targeting toll-like receptor 4 signalling pathways: can therapeutics pay the toll for hypertension?

ABSTRACT: The immune system plays a prominent role in the initiation and maintenance of hypertension. The innate immune system, via toll-like receptors (TLRs), identifies distinct signatures of invading microbes and damage-associated molecular patterns and triggers a chain of downstream signalling cascades, leading to secretion of pro-inflammatory cytokines and shaping the adaptive immune response. Over the past decade, a dysfunctional TLR-mediated response, particularly via TLR4, has been suggested to support a chronic inflammatory state in hypertension, inducing deleterious local and systemic effects in host cells and tissues and contributing to disease progression. While the underlying mechanisms triggering TLR4 need further research, evidence suggests that sustained elevations in BP disrupt home

SUBMITTER: Nunes KP 

PROVIDER: S-EPMC6534778 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature