The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension.

ABSTRACT: Autoimmunity is increasingly recognized as having a central role in essential hypertension. Heat shock proteins (HSPs) are immunodominant molecules with high interspecies homology and autoimmune reactivity directed against HSP70 may play a role in the pathogenesis of hypertension. Autoimmunity to HSP70 may result from molecular mimicry between human HSP and bacterial HSP or, alternatively, as a response to HSP70-peptide complexes generated during cellular stress and delivered to the major histocompatibility complex by antigen-presenting cells. HSP70 is increased in the circulation and kidney of hypertensive patients, and genetic polymorphisms of HSP70 are associated with essential hypertension. Depending on the route and conditions of administration, HSP70 may induce or suppress immune-rel

SUBMITTER: Rodriguez-Iturbe B 

PROVIDER: S-EPMC6534783 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature