Anopheles aquasalis transcriptome reveals autophagic responses to Plasmodium vivax midgut invasion.

ABSTRACT:

Background

Elimination of malaria depends on mastering transmission and understanding the biological basis of Plasmodium infection in the vector. The first mosquito organ to interact with the parasite is the midgut and its transcriptomic characterization during infection can reveal effective antiplasmodial responses able to limit the survival of the parasite. The vector response to Plasmodium vivax is not fully characterized, and its specificities when compared with other malaria parasites can be of fundamental interest for specific control measures.

Methods

Experimental infections were performed using a membrane-feeding device. Three groups were used: P. vivax-blood-fed, blood-fed on inactivated gametocytes, and unfed mosquitoes. Twenty-four hours after feeding, the mosquit

SUBMITTER: Santana RAG 

PROVIDER: S-EPMC6534896 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature