Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine.

ABSTRACT:

Background

In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epitopes. Unfortunately, such T-cell responses are frequently dominated by responses to non-protective, variable epitopes. In this study we attempt to combine three independent approaches, each developed to prevent immunodominance of non-protective epitopes. These approaches were (1) vaccines consisting exclusively of putatively protective p24 Gag highly conserved elements (CEs), (2) vaccines using solely subdominant antigens which were acutely protective in a recent NHP trial, and (3) virus-encoded virus-like particle vaccines (virus-like vaccines/VLVs) using heterologo

SUBMITTER: Schwerdtfeger M 

PROVIDER: S-EPMC6534914 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature