High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers.

ABSTRACT: While study in the field of polymer mechanochemistry has yielded mechanophores that perform various chemical reactions in response to mechanical stimuli, there is not yet a triggering method compatible with biological systems. Applications such as using mechanoluminescence to generate localized photon flux in vivo for optogenetics would greatly benefit from such an approach. Here we introduce a method of triggering mechanophores by using high-intensity focused ultrasound (HIFU) as a remote energy source to drive the spatially and temporally resolved mechanical-to-chemical transduction of mechanoresponsive polymers. A HIFU setup capable of controlling the excitation pressure, spatial location, and duration of exposure is employed to activate mechanochemical reactions in a cross-linked elast

SUBMITTER: Kim G 

PROVIDER: S-EPMC6534979 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature