Rational vaccinology with spherical nucleic acids.

ABSTRACT: In the case of cancer immunotherapy, nanostructures are attractive because they can carry all of the necessary components of a vaccine, including both antigen and adjuvant. Herein, we explore how spherical nucleic acids (SNAs), an emerging class of nanotherapeutic materials, can be used to deliver peptide antigens and nucleic acid adjuvants to raise immune responses that kill cancer cells, reduce (or eliminate) tumor growth, and extend life in three established mouse tumor models. Three SNA structures that are compositionally nearly identical but structurally different markedly vary in their abilities to cross-prime antigen-specific CD8⁺ T cells and raise subsequent antitumor immune responses. Importantly, the most effective structure is the one that exhibits synchronization of

SUBMITTER: Wang S 

PROVIDER: S-EPMC6535021 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature