Ontology highlight
ABSTRACT:
SUBMITTER: Han X
PROVIDER: S-EPMC6535035 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20190430 21
Polymorphic HLAs form the primary immune barrier to cell therapy. In addition, innate immune surveillance impacts cell engraftment, yet a strategy to control both, adaptive and innate immunity, is lacking. Here we employed multiplex genome editing to specifically ablate the expression of the highly polymorphic HLA-A/-B/-C and HLA class II in human pluripotent stem cells. Furthermore, to prevent innate immune rejection and further suppress adaptive immune responses, we expressed the immunomodulat ...[more]