Mesenchymal stem cells for sensorineural hearing loss: protocol for a systematic review of preclinical studies.

ABSTRACT:

Background

Sensorineural hearing loss (SNHL) is the most common form of hearing impairment and is characterized by a loss of receptor hair cells and/or spiral ganglion neurons. Regenerative stem cell therapy could potentially restore normal hearing and slow the progression of hearing loss in patients. Preclinical animal studies have demonstrated that mesenchymal stem cells (MSCs) could be a promising new therapy for this condition. These findings have prompted investigators to begin human clinical trials to assess the safety and efficacy of MSCs for the treatment of SNHL. The objective of the proposed systematic review is to examine the efficacy of MSCs as a therapy for SNHL in animal models.

Methods

We will include preclinical animal studies of SNHL in which MSCs are admini

SUBMITTER: Chorath KT 

PROVIDER: S-EPMC6535185 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature