Transcriptomic study of the mechanism of anoikis resistance in head and neck squamous carcinoma.

ABSTRACT:

Background

Normal epithelial cells rapidly undergo apoptosis as soon as they lose contact with the extracellular matrix (ECM), which is termed as anoikis. However, cancer cells tend to develop a resistance mechanism to anoikis. This acquired ability is termed as anoikis resistance. Cancer cells, with anoikis resistance, can spread to distant tissues or organs via the peripheral circulatory system and cause cancer metastasis. Thus, inhibition of anoikis resistance blocks the metastatic ability of cancer cells.

Methods

Anoikis-resistant CAL27 (CAL27^AR) cells were induced from CAL27 cells using the suspension culture approach. Transcriptome analysis was performed using RNA-Seq to study the differentially expressed genes (DEGs) between the CAL27^ARcells and

SUBMITTER: Guo C 

PROVIDER: S-EPMC6535219 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature