Infliximab trough concentrations during maintenance therapy are associated with endoscopic and histologic healing in ulcerative colitis.

ABSTRACT:

Background

Endoscopic and histologic healing are emerging as new therapeutic goals in ulcerative colitis (UC), as these endpoints are associated with less relapse, hospitalization and colectomy.

Aim

To investigate the association of serum infliximab trough concentrations during maintenance therapy with endoscopic or histologic healing in UC.

Methods

In this multi-center retrospective cohort study, we included consecutive patients with moderate-to-severe UC on infliximab maintenance therapy who had an endoscopic evaluation and underwent therapeutic drug monitoring within three months of the colonoscopy, between February 2008 and March 2016. Per event analysis was performed. Endoscopic healing was defined as Mayo endoscopic sub-score of ≤1. Histologic healing was define

SUBMITTER: Papamichael K 

PROVIDER: S-EPMC6535226 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature