Population Pharmacokinetics and Dosing Optimization of Imipenem in Children with Hematological Malignancies.

ABSTRACT: Imipenem is widely used for the treatment of children with serious infections. Currently, studies on the pharmacokinetics of imipenem in children with hematological malignancies are lacking. Given the significant impact of disease on pharmacokinetics and increased resistance, we aimed to conduct a population pharmacokinetic study of imipenem and optimize the dosage regimens for this vulnerable population. After children were treated with imipenem-cilastatin (IMP-CS), blood samples were collected from the children and the concentrations of imipenem were quantified using high-performance liquid chromatography with UV detection. Then, a population-level pharmacokinetic analysis was conducted using NONMEM software. Data were collected from 56 children (age range, 2.03 to 11.82 years) with hema

SUBMITTER: Dong L 

PROVIDER: S-EPMC6535524 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature