Browse
Submit Data
Databases
API
Help

Dataset Information

8 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Carbapenem-Susceptible OXA-23-Producing Proteus mirabilis in the French Community.

ABSTRACT: Nineteen Proteus mirabilis isolates producing the carbapenemase OXA-23 were recovered over a 2-year period in 19 French hospitalized patients, of whom 12 had community onset infections. The isolates exhibited a slightly reduced susceptibility to carbapenems. Whole-genome analysis revealed that all 19 isolates formed a cluster compared to 149 other?P. mirabilis isolates. Because of its susceptibility to carbapenems, this clone may be misidentified as a penicillinase producer while it constitutes a reservoir of the OXA-23-encoding gene in the community.

SUBMITTER: Potron A

PROVIDER: S-EPMC6535531 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Carbapenem-Susceptible OXA-23-Producing Proteus mirabilis in the French Community.

Potron Anaïs A Hocquet Didier D Triponney Pauline P Plésiat Patrick P Bertrand Xavier X Valot Benoit B

Antimicrobial agents and chemotherapy 20190524 6

Nineteen <i>Proteus mirabilis</i> isolates producing the carbapenemase OXA-23 were recovered over a 2-year period in 19 French hospitalized patients, of whom 12 had community onset infections. The isolates exhibited a slightly reduced susceptibility to carbapenems. Whole-genome analysis revealed that all 19 isolates formed a cluster compared to 149 other <i>P. mirabilis</i> isolates. Because of its susceptibility to carbapenems, this clone may be misidentified as a penicillinase producer while i ...[more]

PMID: 30962345

Similar Datasets

First report of an OXA-48-producing multidrug-resistant Proteus mirabilis strain from Gaza, Palestine.

Project description: Not available

| S-EPMC4468693 | biostudies-literature

A single Proteus mirabilis lineage from human and animal sources: a hidden reservoir of OXA-23 or OXA-58 carbapenemases in Enterobacterales.

Project description: Not available

| S-EPMC7280188 | biostudies-literature

Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.

Project description: Not available

| S-EPMC2346634 | biostudies-literature

Proteus mirabilis mrpJ microarrays

Project description:This series of microarrays compares gene expression by the bacterial pathogen Proteus mirabilis when the transcriptional regulator mrpJ is deleted or induced to levels found during experimental urinary tract infection. The enteric bacterium Proteus mirabilis is associated with a significant number of catheter-associated urinary tract infections. Strict regulation of the antagonistic processes of adhesion and motility, mediated by fimbriae and flagella, respectively, is essential for successful disease progression. Previously, the transcriptional regulator MrpJ, which is encoded by the mrp fimbrial operon, has been shown to repress both swimming and swarming motility. Here we show that MrpJ affects a wide array of cellular processes beyond adherence and motility. Microarray analysis found that expression of mrpJ mimicking expression levels that occur during UTI leads to differential expression of 217 genes related to, among others, bacterial virulence, type VI secretion and metabolism. We probed the molecular mechanism of transcriptional regulation through MrpJ using reporter assays and chromatin immunoprecipitation (ChIP). Two virulence-associated target genes, the flagellar master regulator flhDC and mrp itself, appear to be regulated through a binding site proximal to the transcriptional start, complemented by a more distantly situated enhancer site. Furthermore, an mrpJ deletion mutant colonized the bladders of mice at significantly lower levels in a transurethral model of infection. Additionally, we observe that mrpJ is widely conserved in a collection of recent clinical isolates, leading us to conclude that our results elucidate an unanticipated role of MrpJ as a global regulator of P. mirabilis virulence.

2015-04-13 | GSE63321 | GEO

Proteus mirabilis mrpJ microarrays

2015-04-13 | E-GEOD-63321 | biostudies-arrayexpress

Proteus mirabilis MrpJ ChIP-seq

Project description:Proteus mirabilis is a leading cause of catheter-associated urinary tract infections (UTIs) and urolithiasis. The transcriptional regulator MrpJ inversely modulates two critical aspects of P. mirabilis UTI progression: fimbria-mediated attachment to the urinary tract, and flagella-mediated motility. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) was used for the first time in a CAUTI pathogen to probe for in vivo direct targets of MrpJ. ChIP-seq revealed 81 78 direct MrpJ targets, including genes for motility, fimbriae and a type VI secretion system (T6SS), and the putative MrpJ binding sequence ACnCnnnnnnnGnGT.

2018-08-10 | GSE96042 | GEO

Genome sequence of OXA-23 producing Acinetobacter baumannii IHIT7853, a carbapenem-resistant strain from a cat belonging to international clone IC1.

Project description: Not available

| S-EPMC4964143 | biostudies-literature

Transcriptome of swarming Proteus mirabilis.

Project description: Not available

| S-EPMC2876570 | biostudies-literature

Infection control response to an outbreak of OXA-23 carbapenemase-producing carbapenem-resistant Acinetobacter baumannii in a skilled nursing facility in Utah.

Project description: Not available

| S-EPMC8803644 | biostudies-literature

The transcriptome of swarming Proteus mirabilis

Project description:This SuperSeries is composed of the SubSeries listed below.