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Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products.

ABSTRACT: Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A β-lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.

SUBMITTER: Brouwer MSM 

PROVIDER: S-EPMC6535546 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Novel Carbapenemases FLC-1 and IMI-2 Encoded by an Enterobacter cloacae Complex Isolated from Food Products.

Brouwer Michael S M MSM   Tehrani Kamaleddin H M E KHME   Rapallini Michel M   Geurts Yvon Y   Kant Arie A   Harders Frank F   Mashayekhi Vida V   Martin Nathaniel I NI   Bossers Alex A   Mevius Dik J DJ   Wit Ben B   Veldman Kees T KT  

Antimicrobial agents and chemotherapy 20190524 6

Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an <i>Enterobacter cloacae</i> complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A β-lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against  ...[more]

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