Optimization of submerged fermentation process for improved production of β-carotene by Exiguobacterium acetylicum S01.

ABSTRACT: Carotenoids are natural pigments with substantial applications in nutraceutical, pharmaceutical, and food industries. In this study, optimization of the fermentation process for enhancement of β-carotene and biomass production by Exiguobacterium acetylicum S01 was achieved by employing statistical designs including the Placket-Burman design (PBD) and response surface methodology (RSM). Among the seven variables investigated by two levels in PBD, glucose, peptone, pH and temperature were indicated as crucial variables (p < 0.0001) for β-carotene and biomass productivity. Response surface methodology was further applied to evaluate the optimal concentrations of these four variables for maximum β-carotene and biomass productivity. The optimized medium contained glucose 1.4 g/L,

SUBMITTER: Jinendiran S 

PROVIDER: S-EPMC6535579 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature