A model of amygdala function following plastic changes at specific synapses during extinction.

ABSTRACT: The synaptic networks in the amygdala have been the subject of intense interest in recent times, primarily because of the role of this structure in emotion. Fear and its extinction depend on the workings of these networks, with particular interest in extinction because of its potential to ameliorate adverse symptoms associated with post-traumatic stress disorder. Here we place emphasis on the extinction networks revealed by recent techniques, and on the probable plasticity properties of their synaptic connections. We use modules of neurons representing each of the principal components identified as involved in extinction. Each of these modules consists of neural networks, containing specific ratios of excitatory and specialized inhibitory neurons as well as synaptic plasticity mechanisms a

SUBMITTER: Bennett MR 

PROVIDER: S-EPMC6535631 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature