Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity.

ABSTRACT: The metagenome of the gut microbiome encodes tremendous potential for biosynthesizing and transforming small-molecule metabolites through the activities of enzymes expressed by intestinal bacteria. Accordingly, elucidating this metabolic network is critical for understanding how the gut microbiota contributes to health and disease. Bile acids, which are first biosynthesized in the liver, are modified in the gut by enzymes expressed by commensal bacteria into secondary bile acids, which regulate myriad host processes, including lipid metabolism, glucose metabolism, and immune homeostasis. The gateway reaction of secondary bile acid biosynthesis is mediated by bile salt hydrolases (BSHs), bacterial cysteine hydrolases whose action precedes other bile acid modifications within the gut. To ass

SUBMITTER: Parasar B 

PROVIDER: S-EPMC6535767 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature