Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications.

ABSTRACT: There is growing evidence that regions of the genome that cannot encode proteins play an important role in diseases. These regions are usually transcribed into long non-coding RNAs (lncRNAs). LncRNAs, little or no coding potential, are defined as capped transcripts longer than 200 nucleotides. New sequencing technologies have shown that a large number of aberrantly expressed lncRNAs are associated with multiple cancer types and indicated they have emerged as an important class of pervasive genes during the development and progression of cancer. However, the underlying mechanism in cancer is still unknown. Therefore, it is necessary to elucidate the lncRNA function. Notably, many lncRNAs dysregulation are associated with Oral squamous cell carcinoma (OSCC) and affect various aspects of cell

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6535863 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature