Animal models of closed-skull, repetitive mild traumatic brain injury.

ABSTRACT: The underlying mechanisms that result in neurophysiological changes and cognitive sequelae in the context of repetitive mild traumatic brain injury (rmTBI) remain poorly understood. Animal models provide a unique opportunity to examine cellular and molecular responses using histological assessment, which can give important insights on the neurophysiological changes associated with the evolution of brain injury. To better understand the potential cumulative effects of multiple concussions, the focus of animal models is shifting from single to repetitive head impacts. With a growing body of literature on this subject, a review and discussion of current findings is valuable to better understand the neuropathology associated with rmTBI, to evaluate the current state of the field, and to guide

SUBMITTER: Hoogenboom WS 

PROVIDER: S-EPMC6536340 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature