Adaptive NK cell responses in HIV/SIV infections: A roadmap to cell-based therapeutics?

ABSTRACT: NK cells play a critical role in antiviral and antitumor responses. Although current NK cell immune therapies have focused primarily on cancer biology, many of these advances can be readily applied to target HIV/simian immunodeficiency virus (SIV)-infected cells. Promising developments include recent reports that CAR NK cells are capable of targeted responses while producing less off-target and toxic side effects than are associated with CAR T cell therapies. Further, CAR NK cells derived from inducible pluripotent stem cells or cell lines may allow for more rapid "off-the-shelf" access. Other work investigating the IL-15 superagonist ALT-803 (now N803) may also provide a recourse for enhancing NK cell responses in the context of the immunosuppressive and inflammatory environment of chroni

SUBMITTER: Ram DR 

PROVIDER: S-EPMC6536345 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature