Correlation over time of toenail metals among participants in the VA normative aging study from 1992 to 2014.

ABSTRACT:

Background

Scientists use biomarkers to evaluate metal exposures. One biomarker, toenails, is easily obtained and minimally invasive, but less commonly used as a biomarker of exposure. Their utility will depend on understanding characteristics of their variation in a population over time. The objective of our study is to describe the correlation of toenail metal levels many years apart among participants in the VA Normative Aging Study (NAS).

Methods

Toenail clippings from 825 participants of the NAS from year 1992 to 2014 were analyzed for lead (Pb), Arsenic (As), Cadmium (Cd), Manganese (Mn), and Mercury (Hg). We utilized linear mixed models to assess correlation between toenail metal concentrations in multiple toenail samples from the same subject collected years apart an

SUBMITTER: Wu AC 

PROVIDER: S-EPMC6536369 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature