Dynamics of Insulin Signaling in the Black-Legged Tick, Ixodes scapularis.

ABSTRACT: Insulin-like peptides (ILPs) have been identified in several invertebrates, particularly insects, and work on these ILPs has revealed many roles including regulation of energy homeostasis, growth, development, and lifespan to name a few. However, information on arthropod ILPs outside of insects is sparse. Studies of Ixodid tick ILPs are particularly scarce, despite their importance as vectors of infectious agents, most notably Lyme disease. The recent publication of the genome of the black-legged tick, Ixodes scapularis, has advanced opportunities to study this organism from a molecular standpoint, a resource sorely needed for an organism with challenging life history requirements for study in the laboratory, such as a long life cycle and obligate, prolonged, blood-feeding at each l

SUBMITTER: Sharma A 

PROVIDER: S-EPMC6536706 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature