Outcomes from an inpatient beta-lactam allergy guideline across a large US health system.

ABSTRACT: OBJECTIVE:To assess the safety of, and subsequent allergy documentation associated with, an antimicrobial stewardship intervention consisting of test-dose challenge procedures prompted by an electronic guideline for hospitalized patients with reported β-lactam allergies. DESIGN:Retrospective cohort study. SETTING:Large healthcare system consisting of 2 academic and 3 community acute-care hospitals between April 2016 and December 2017. METHODS:We evaluated β-lactam antibiotic test-dose outcomes, including adverse drug reactions (ADRs), hypersensitivity reactions (HSRs), and electronic health record (EHR) allergy record updates. HSR predictors were examined using a multivariable logistic regression model. Modification of the EHR allergy record after test doses considered relevant allergy ent

SUBMITTER: Blumenthal KG 

PROVIDER: S-EPMC6536839 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature