Amikacin exposure and susceptibility of macrolide-resistant Mycobacterium abscessus.

ABSTRACT: Mycobacterium abscessus is associated with antibiotic resistance and poor treatment outcomes. We described within-patient changes in M. abscessus resistance to clarithromycin and amikacin. Patients with amikacin exposure and a >50-month interval between M. abscessus isolates were identified. Antimicrobial susceptibility testing was performed on the first and last isolates by broth microdilution, and genetic markers of resistance were identified. 16 patients were identified with a median amikacin exposure of 2.3 years (range 0.6-8.6 years). 15 patients also received macrolides (median 7.2 years, range 1.3-10.7 years). All initial isolates were resistant to clarithromycin (minimum inhibitory concentration (MIC) ≥8 µg·mL^-1). Two patients had later susceptible i

SUBMITTER: Daniel-Wayman S 

PROVIDER: S-EPMC6536947 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature