A genetic variant in miR-100 is a protective factor of childhood acute lymphoblastic leukemia.

ABSTRACT:

Background

In the past decade, miR-100, miR-146a, and miR-210 were reported to be dysregulated in childhood acute lymphoblastic leukemia (ALL). However, effects of genetic variants in these three microRNAs have not been investigated in Chinese population.

Methods

In this study, we conducted a case-control study to evaluate the relationship between genetic variants in miR-100, miR-146a, and miR-210 and the risk of childhood ALL in Chinese population. Subsequently, plasma expression level of miR-100 was also detected.

Result

We found that subjects carrying mutant homozygous TT genotype of miR-100 rs543412 had a statistically significantly decreased risk of childhood ALL (adjusted odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.55-0.97, P = 0.029). This protecti

SUBMITTER: Xue Y 

PROVIDER: S-EPMC6536980 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature