Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas.

ABSTRACT:

Purpose

Gliomas with isocitrate dehydrogenase 1 mutations (IDH1^mut) are less aggressive than IDH1 wild-type (IDH1^wt) gliomas and have global genomic hypermethylation. Yet it is unclear how specific hypermethylation events contribute to the IDH1^mut phenotype. Previously, we showed that the gene encoding the procoagulant tissue factor (TF), F3, is among the most hypermethylated and downregulated genes in IDH1^mut gliomas, correlating with greatly reduced thrombosis in patients with IDH1^mut glioma. Because TF also increases the aggressiveness of many cancers, the current study explored the contribution of TF suppression to the reduced malignancy of IDH1^mut gliomas.Experimental Design: TF expression w

SUBMITTER: Unruh D 

PROVIDER: S-EPMC6537089 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature