Temporal lobe epilepsy: Hippocampal pathology modulates connectome topology and controllability.

ABSTRACT:

Objective

To assess whether hippocampal sclerosis (HS) severity is mirrored at the level of large-scale networks.

Methods

We studied preoperative high-resolution anatomical and diffusion-weighted MRI of 44 temporal lobe epilepsy (TLE) patients with histopathologic diagnosis of HS (n = 25; TLE-HS) and isolated gliosis (n = 19; TLE-G) and 25 healthy controls. Hippocampal measurements included surface-based subfield mapping of atrophy and T2 hyperintensity indexing cell loss and gliosis, respectively. Whole-brain connectomes were generated via diffusion tractography and examined using graph theory along with a novel network control theory paradigm that simulates functional dynamics from structural network data.

Results

Compared to controls, we observed markedly increased

SUBMITTER: Bernhardt BC 

PROVIDER: S-EPMC6537128 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature