Study protocol for a randomized, blinded, controlled trial of ketamine for acute painful crisis of sickle cell disease.

ABSTRACT:

Background

Sickle cell disease (SCD) is an inherited hematological disorder where the shape of red blood cells is altered, resulting in the destruction of red blood cells, anemia, and other complications. SCD is prevalent in the southern and eastern provinces of the Arabian peninsula. The most common complications for individuals with SCD are acute painful episodes that require several doses of intravenous opioids, making pain control for these individuals challenging. Instead of opioids, some studies have suggested that ketamine might be used for pain control in acute pain episodes of individuals with SCD. This study aims to evaluate whether the addition of ketamine to morphine can achieve better pain control, decreasing the number of repeated doses of opiates. We hypothesize that

SUBMITTER: Alshahrani MS 

PROVIDER: S-EPMC6537144 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature