Albumin infusion rate and plasma volume expansion: a randomized clinical trial in postoperative patients after major surgery.

ABSTRACT:

Background

Optimal infusion rate of colloids in patients with suspected hypovolemia is unknown, and the primary objective of the present study was to test if plasma volume expansion by 5% albumin is greater if fluid is administered slowly rather than rapidly.

Methods

Patients with signs of hypoperfusion after major abdominal surgery were randomized to intravenous infusion of 5% albumin at a dose of 10 ml/kg (ideal body weight) either rapidly (30 min) or slowly (180 min). Plasma volume was measured using radiolabeled albumin at baseline, at 30 min, and at 180 min after the start of infusion. Primary outcome was change in plasma volume from the start of infusion to 180 min after the start of infusion. Secondary outcomes included the change in the area under the plasma volume c

SUBMITTER: Statkevicius S 

PROVIDER: S-EPMC6537197 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature