Ellagic acid microspheres restrict the growth of Babesia and Theileria in vitro and Babesia microti in vivo.

ABSTRACT:

Background

There are no effective vaccines against Babesia and Theileria parasites; therefore, therapy depends heavily on antiprotozoal drugs. Treatment options for piroplasmosis are limited; thus, the need for new antiprotozoal agents is becoming increasingly urgent. Ellagic acid (EA) is a polyphenol found in various plant products and has antioxidant, antibacterial and effective antimalarial activity in vitro and in vivo without toxicity. The present study documents the efficacy of EA and EA-loaded nanoparticles (EA-NPs) on the growth of Babesia and Theileria.

Methods

In this study, the inhibitory effect of EA, β-cyclodextrin ellagic acid (β-CD EA) and antisolvent precipitation with a syringe pump prepared ellagic acid (APSP EA) was evaluated on four Babesia species and Th

SUBMITTER: Beshbishy AM 

PROVIDER: S-EPMC6537213 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature