Identification of variants and therapeutic epitopes in HPV-33/HPV-58 E6 and E7 in Southwest China.

ABSTRACT:

Background

Human papillomavirus (HPV) E6 and E7 oncoproteins play a crucial role in HPV-related diseases, such as cervical cancer, and can be used as ideal targets for therapeutic vaccines. Human leukocyte antigen (HLA) participates in the immune response to block HPV infection and invasion by its target/recognition function. HPV-33 and HPV-58 are highly prevalent among Chinese women. Therefore, it is of great significance to study the E6 and E7 region-specific gene polymorphisms of HPV-33 and HPV-58 in Southwest China and to identify ideal epitopes for vaccine design. Both HPV-33 and HPV-58 belong to α-9 genus HPV and are highly homologous, so their correlations are included in our research.

Methods

To study the E6 and E7 variations and polymorphisms of HPV-33 and HPV-58 in

SUBMITTER: He J 

PROVIDER: S-EPMC6537359 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature