Determination of genetic associations between indels in 11 candidate genes and milk composition traits in Chinese Holstein population.

ABSTRACT:

Background

We have previously identified 11 promising candidate genes for milk composition traits by resequencing the whole genomes of 8 Holstein bulls with extremely high and low estimated breeding values for milk protein and fat percentages (high and low groups), including FCGR2B, CENPE, RETSAT, ACSBG2, NFKB2, TBC1D1, NLK, MAP3K1, SLC30A2, ANGPT1 and UGDH those contained 25 indels between high and low groups. In this study, the purpose was to further examine whether these candidates have significant genetic effects on milk protein and fat traits.

Results

With PCR product sequencing, 13 indels identified by whole genome resequencing were successfully genotyped. With association analysis in 769 Chinese Holstein cows, we found that the indel in FCGR2B was significantly associ

SUBMITTER: Jiang J 

PROVIDER: S-EPMC6537361 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature