Comprehensive analysis of key genes and microRNAs in radioresistant nasopharyngeal carcinoma.

ABSTRACT:

Background

Radioresistance is one of the main obstacle limiting the therapeutic efficacy and prognosis of patients, the molecular mechanisms of radioresistance is still unclear. The purpose of this study was to identify the key genes and miRNAs and to explore their potential molecular mechanisms in radioresistant nasopharyngeal carcinoma.

Methods

In this study, we analysis the differentially expressed genes and microRNA based on the database of GSE48501 and GSE48502, and then employed bioinformatics to analyze the pathways and GO terms in which DEGs and DEMS target genes are involved. Moreover, Construction of protein-protein interaction network and identification of hub genes. Finally, analyzed the biological networks for validated target gene of hub miRNAs.

Results

SUBMITTER: Guo Y 

PROVIDER: S-EPMC6537399 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature