Cancer cell lipid class homeostasis is altered under nutrient-deprivation but stable under hypoxia.

ABSTRACT:

Background

Cancer cells modify the balance between fatty acid (FA) synthesis and uptake under metabolic stress, induced by oxygen/nutrient deprivation. These modifications were shown to alter the levels of individual triglyceride (TG) or phospholipid sub-species. To attain a holistic overview of the lipidomic profiles of cancer cells under stress we performed a broad lipidomic assay, comprising 244 lipids from six major classes. This assay allowed us to perform robust analyses and assess the changes in averages of broader lipid-classes, stratified on the basis of saturation index of their fatty-acyl side chains.

Methods

Global lipidomic profiling using Liquid Chromatography-Mass Spectrometry was performed to assess lipidomic profiles of biologically diverse cancer cell lines

SUBMITTER: Lisec J 

PROVIDER: S-EPMC6537432 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature