Sex differences in COPD-related quadriceps muscle dysfunction and fibre abnormalities.

ABSTRACT: In chronic obstructive pulmonary disease (COPD), lower limb dysfunction is associated with reduced exercise capacity, increased hospitalizations and mortality. We investigated sex differences in the prevalence of quadriceps dysfunction and fibre abnormalities in a large COPD cohort, controlling for the normal sex differences in health. We compared existing data from 76 male and 38 female COPD patients where each variable was expressed as a function of gender-specific normal values (obtained from 16 male and 14 female controls). Female COPD patients had lower quadriceps muscle strength and peak workload on a maximal incremental cycle ergometry protocol compared to male patients. Female patients had a smaller type II fibre cross-sectional area (CSA) compared to male patients, suggesting a gr

SUBMITTER: Sharanya A 

PROVIDER: S-EPMC6537500 | biostudies-literature | 2019 Jan-Dec

REPOSITORIES: biostudies-literature