Metformin Monotherapy Downregulates Diabetes-Associated Inflammatory Status and Impacts on Mortality.

ABSTRACT: Aging is the main risk factor for developing diabetes and other age-related diseases. One of the most common features of age-related comorbidities is the presence of low-grade chronic inflammation. This is also the case of metabolic syndrome and diabetes. At the subclinical level, a pro-inflammatory phenotype was shown to be associated with Type-2 diabetes mellitus (T2DM). This low to mid-grade inflammation is also present in elderly individuals and has been termed inflammaging. Whether inflammation is a component of aging or exclusively associated with age-related diseases in not entirely known. We used clinical data and biological readouts in a group of individuals stratified by age, diabetes status and comorbidities to investigate this aspect. While aging is the main predisposing factor

SUBMITTER: Tizazu AM 

PROVIDER: S-EPMC6537753 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature