Association Between Statin Use and Risk of Dementia After a Concussion.

ABSTRACT:

Importance

Concussions are an acute injury that may lead to chronic disability, while statin use might improve neurologic recovery.

Objective

To test whether statin use is associated with an increased or decreased risk of subsequent dementia after a concussion.

Design, setting, and participants

Large extended population-based double cohort study in Ontario, Canada, from April 1, 1993, to April 1, 2013 (enrollment), and continued until March 31, 2016 (follow-up). Dates of analysis were April 28, 2014, through March 21, 2019. Participants were older adults diagnosed as having a concussion, excluding severe cases resulting in hospitalization, individuals with a prior diagnosis of dementia or delirium, and those who died within 90 days.

Exposure

Statin prescription

SUBMITTER: Redelmeier DA 

PROVIDER: S-EPMC6537780 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature