Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.

ABSTRACT:

Importance

Anxiety and stress-related disorders are among the most common mental disorders. Although family and twin studies indicate that both genetic and environmental factors play an important role underlying their etiology, the genetic underpinnings of anxiety and stress-related disorders are poorly understood.

Objectives

To estimate the single-nucleotide polymorphism-based heritability of anxiety and stress-related disorders; to identify novel genetic risk variants, genes, or biological pathways; to test for pleiotropic associations with other psychiatric traits; and to evaluate the association of psychiatric comorbidities with genetic findings.

Design, setting, participants

This genome-wide association study included individuals with various anxiety and stress-r

SUBMITTER: Meier SM 

PROVIDER: S-EPMC6537792 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature