Adolescent cannabis use and brain systems supporting adult working memory encoding, maintenance, and retrieval.

ABSTRACT: Given prior reports of adverse effects of cannabis use on working memory, an executive function with a protracted developmental course during adolescence, we examined associations between developmental patterns of cannabis use and adult working memory (WM) processes. Seventy-five adults with longitudinal assessments of cannabis use (60 with reported use, 15 with no reported use) and prenatal drug exposure assessment completed a spatial WM task during fMRI at age 28. All subjects passed a multi-drug urine screen on the day of testing and denied recreational drug use in the past week. A fast event-related design with partial trials was used to separate the BOLD response associated with encoding, maintenance, and retrieval periods of the WM task. Behavioral results showed that subjects who be

SUBMITTER: Tervo-Clemmens B 

PROVIDER: S-EPMC6537905 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature