New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.

ABSTRACT:

Background

Individual differences in human perception of sweetness are partly due to genetics; however, which genes are associated with the perception and the consumption of sweet substances remains unclear.

Objective

The aim of this study was to verify previous reported associations within genes involved in the peripheral receptor systems (i.e., TAS1R2, TAS1R3, and GNAT3) and reveal novel loci.

Methods

We performed genome-wide association scans (GWASs) of the perceived intensity of 2 sugars (glucose and fructose) and 2 high-potency sweeteners (neohesperidin dihydrochalcone and aspartame) in an Australian adolescent twin sample (n = 1757), and the perceived intensity and sweetness and the liking of sucrose in a US adult twin sample (n = 686). We further performed GWAS

SUBMITTER: Hwang LD 

PROVIDER: S-EPMC6537940 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature