Creation of a database to assess effects of omega-3, omega-6 and total polyunsaturated fats on health: methodology for a set of systematic reviews.

ABSTRACT:

Objective

To create a database of long-term randomised controlled trials (RCTs) comparing higher with lower omega-3, omega-6 or total polyunsaturated fatty acid (PUFA), regardless of reported outcomes, and to develop methods to assess effects of increasing omega-6, alpha-linolenic acid (ALA), long-chain omega-3 (LCn3) and total PUFA on health outcomes.

Design

Systematic review search, methodology and meta-analyses.

Data sources

Medline, Embase, CENTRAL, WHO International Clinical Trials Registry Platform, Clinicaltrials.gov and trials in relevant systematic reviews.

Eligibility criteria

RCTs of ≥24 weeks' duration assessing effects of increasing ALA, LCn3, omega-6 or total PUFAs, regardless of outcomes reported.

Data synthesis

Methods included random-eff

SUBMITTER: Hooper L 

PROVIDER: S-EPMC6537970 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature