Treatment as prevention for hepatitis C virus in Pakistan: mathematical modelling projections.

ABSTRACT:

Objective

Direct-acting antivirals have opened an opportunity for controlling hepatitis C virus (HCV) infection in Pakistan, where 10% of the global infection burden is found. We aimed to evaluate the implications of five treatment programme scenarios for HCV treatment as prevention (HCV-TasP) in Pakistan.

Design

An age-structured mathematical model was used to evaluate programme impact using epidemiological and programme indicators.

Setting

Total Pakistan population.

Participants

Total Pakistan HCV-infected population.

Interventions

HCV treatment programme scenarios from 2018 up to 2030.

Results

By 2030 across the five HCV-TasP scenarios, 0.6-7.3 million treatments were administered, treatment coverage reached between 3.7% and 98.7%, prevalence o

SUBMITTER: Ayoub HH 

PROVIDER: S-EPMC6537971 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature