Importance of vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To estimate the prevalence of 25-hydroxyvitamin D (25(OH)D) deficiency and investigate its association with mortality in children with acute or critical conditions.

Design

Systematic review and meta-analysis of observational studies.

Data sources

PubMed, OVID, Google Scholar and the Cochrane Library searched until 21 December 2018.

Eligibility criteria

Studies of children hospitalised with acute or critical conditions who had blood 25(OH)D levels measured.

Data extraction and synthesis

We obtained pooled prevalence estimates of 25(OH)D deficiency and ORs for mortality. We calculated 95% CI and prediction intervals and investigated heterogeneity and evidence of small-study effects.

Results

Fifty-two studies were included. Of 7434 childre

SUBMITTER: Cariolou M 

PROVIDER: S-EPMC6538078 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature