Prolonged infusion with β-lactam antibiotics for treatment of infection caused by non-susceptible bacteria: a study protocol for a systemic review and meta-analysis.

ABSTRACT:

Introduction

Prolonged infusion with β-lactam antibiotics should theoretically produce a better clinical efficacy than intermittent infusion in severe infection and infection caused by non-susceptible micro-organisms. The efficacy of prolonged infusion in severe infection has been well illustrated recently, but is still confusing in non-susceptible microbial infection. The objective of this meta-analysis is to determine the clinical effects of prolonged infusion with β-lactams for patients infected by microbes non-susceptible to the given drug.

Methods and analysis

Literature searches will be performed with Medline, the Cochrane database, EMBASE database, Cumulative Index to Nursing and Allied Health Literature database, the Chinese National Knowledge Infrastructure and Wanf

SUBMITTER: Chen H 

PROVIDER: S-EPMC6538082 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature