MNM and SNM maintain but do not establish achiasmate homolog conjunction during Drosophila male meiosis.

ABSTRACT: The first meiotic division reduces genome ploidy. This requires pairing of homologous chromosomes into bivalents that can be bi-oriented within the spindle during prometaphase I. Thereafter, pairing is abolished during late metaphase I, and univalents are segregated apart onto opposite spindle poles during anaphase I. In contrast to canonical meiosis, homologous chromosome pairing does not include the formation of a synaptonemal complex and of cross-overs in spermatocytes of Drosophila melanogaster. The alternative pairing mode in these cells depends on mnm and snm. These genes are required exclusively in spermatocytes specifically for successful conjunction of chromosomes into bivalents. Available evidence suggests that MNM and SNM might be part of a physical linkage that directly conjoin

SUBMITTER: Sun MS 

PROVIDER: S-EPMC6538143 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature