Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines.

ABSTRACT: Model simulations indicate that the response of growing cell populations on mechanical stress follows the same functional relationship and is predictable over different cell lines and growth conditions despite experimental response curves look largely different. We develop a hybrid model strategy in which cells are represented by coarse-grained individual units calibrated with a high resolution cell model and parameterized by measurable biophysical and cell-biological parameters. Cell cycle progression in our model is controlled by volumetric strain, the latter being derived from a bio-mechanical relation between applied pressure and cell compressibility. After parameter calibration from experiments with mouse colon carcinoma cells growing against the resistance of an elastic alginate caps

SUBMITTER: Van Liedekerke P 

PROVIDER: S-EPMC6538187 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature