In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination.

ABSTRACT:

Background

Schistosomiasis is a neglected disease affecting hundreds of millions worldwide. Of the three main species affecting humans, Schistosoma haematobium is the most common, and is the leading cause of urogenital schistosomiasis. S. haematobium infection can cause different urogenital clinical complications, particularly in the bladder, and furthermore, this parasite has been strongly linked with squamous cell carcinoma. A comprehensive analysis of the molecular composition of its different proteomes will contribute to developing new tools against this devastating disease.

Methods and findings

By combining a comprehensive protein fractionation approach consisting of OFFGEL electrophoresis with high-throughput mass spectrometry, we have performed the first in-depth char

SUBMITTER: Sotillo J 

PROVIDER: S-EPMC6538189 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature