Longevity Effect of Liuwei Dihuang in Both Caenorhabditis Elegans and Aged Mice.

ABSTRACT: Liuwei Dihuang (LWDH), a famous traditional Chinese medicine, is widely used in the clinical treatment of aging-related diseases in China. However, its pharmacological mechanisms are not clear. In the present study, we evaluated the lifespan extension effect of LWDH in C. elegans and mice and revealed its underlying mechanisms. The results showed that LWDH significantly extended the lifespan of C. elegans in a dose-dependent manner. LWDH also conferred protection to nematodes against oxidative stress and reduced their fat storage. Genetics analysis and microarray data showed that the longevity effect of LWDH was attributed to the regulation of the innate immune response, proteolysis, lipid metabolism, and the oxidation-reduction process and was dependent on daf-16. Amo

SUBMITTER: Chen W 

PROVIDER: S-EPMC6538212 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature