Sustained release silk fibroin discs: Antibody and protein delivery for HIV prevention.

ABSTRACT: With almost 2 million new HIV infections worldwide each year, the prevention of HIV infection is critical for stopping the pandemic. The only approved form of pre-exposure prophylaxis is a costly daily pill, and it is recognized that several options will be needed to provide protection to the various affected communities around the world. In particular, many at-risk people would benefit from a prevention method that is simple to use and does not require medical intervention or a strict daily regimen. We show that silk fibroin protein can be formulated into insertable discs that encapsulate either an antibody (IgG) or the potent HIV inhibitor 5P12-RANTES. Several formulations were studied, including silk layering, water vapor annealing and methanol treatment to stabilize the protein cargo a

SUBMITTER: Yavuz B 

PROVIDER: S-EPMC6538278 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature